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Guidelines for establishing locus specific databases.

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Author

  • Mauno Vihinen
  • Johan T den Dunnen
  • Raymond Dalgleish
  • Richard G H Cotton

Summary, in English

Information about genetic variation has been collected for some 20 years into registries, known as locus specific databases (LSDBs), which nowadays often contain information in addition to the actual genetic variation. Several issues have to be taken into account when considering establishing and maintaining LSDBs and these have been discussed previously in a number of articles describing guidelines and recommendations. This information is widely scattered and, for a newcomer, it would be difficult to obtain the latest information and guidance. Here, a sequence of steps essential for establishing an LSDB is discussed together with guidelines for each step. Curators need to collect information from various sources, code it in systematic way, and distribute to the research and clinical communities. In doing this, ethical issues have to be taken into account. To facilitate integration of information to, for example, analyze genotype-phenotype correlations, systematic data representation using established nomenclatures, data models, and ontologies is essential. LSDB curation and maintenance comprises a number of tasks that can be managed by following logical steps. These resources are becoming ever more important and new curators are essential to ensure that we will have expertly curated databases for all disease-related genes in the near future.

Publishing year

2012

Language

English

Pages

298-305

Publication/Series

Human Mutation

Volume

33

Issue

2

Document type

Journal article

Publisher

John Wiley & Sons Inc.

Topic

  • Medical Genetics

Keywords

  • Databases
  • Computational Biology: methods
  • Computational Biology: standards
  • Genetic: ethics
  • Genetic: standards

Status

Published

ISBN/ISSN/Other

  • ISSN: 1059-7794