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An Improved Procedure for the Synthesis of Bicyclo[2.2.2]octane- 2,6-dione

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Author

Summary, in English

Conjugate addition of Meldrum's acid to 2-cyclohexenone followed by direct cyclization in PPA/acetic acid constitutes a shorter, more reproducible and higher yielding route to bicyclo[2.2.2]octane-2,6-dione than previous methods. The crude dione could be used as substrate for the baker's yeast reduction to (IR, 4S, 6S)-bicyclo[2.2.2]octane-6-ol-2-one.

Publishing year

1993

Language

English

Pages

1499-1505

Publication/Series

Synthetic Communications

Volume

23

Issue

11

Document type

Journal article

Publisher

Marcel Dekker

Topic

  • Organic Chemistry

Status

Published

ISBN/ISSN/Other

  • ISSN: 0039-7911