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Biological supercomputers to be powered by molecular motors

Illustration of a network-based biocomputer (Till Korten)
Illustration of a network-based biocomputer (Till Korten)

Crashing computers or smartphones - and security loopholes that allow hackers to steal millions of passwords - could be prevented if it were possible to design error-free software. To date, this is a problem that neither engineers nor current supercomputers have been able to solve.

A major reason for this is the computing power required to verify large programs. Today’s computers use vast amounts of electric power – so much so that the inability to cool the processors actually hampers the development of more powerful computers. In addition, they cannot do two things at the same time, which affects the processing speed needed.

The EU is now funding a large project that aims to develop technology for an extremely powerful computer based on highly efficient molecular motors. The motors will use a fraction of the energy of existing computers, and will be able to tackle problems where many solutions need to be explored simultaneously.

"One of the most exciting aspects of network-based computing with molecular motors is that it needs hundred to thousand times less energy than electronic computers.", says Professor Heiner Linke, Director of the NanoLund Center for Nanoscience at Lund University and coordinator of the project.

“Practically all really interesting mathematical problems of our time cannot be computed efficiently with our current computer technology.” adds Dan V. Nicolau, Ph.D. M.D., from the UK-based enterprise Molecular Sense, who had the original idea of using biomolecular motors as computers.

How it Works

The idea is that biomolecular machines, each only a few billionth of a meter (nanometers) in size, can solve problems by moving through a nanofabricated network of channels designed to represent a mathematical algorithm - an approach they call “network-based biocomputation”.

Whenever the biomolecules reach a junction in the network, they can decide to add a number to the sum they are calculating or leave it out. That way, each of the myriad of biomolecules acts as a tiny computer with processor and memory.

While an individual biomolecule is much slower than a current computer, they are self-assembling so that they can be used in large numbers, quickly adding up their computing power. The researchers have demonstrated that this works in a publication in the prestigious scientific periodical PNAS.

”The biological computing units can multiply themselves to adapt to the difficulty of the mathematical problem”, explains Till Korten, Ph.D. from TU Dresden, co-coordinator of the project.

About the research project:

The five-year project Bio4Comp (2017-2021) is funded by Horizon 2020, the EU framework program for Research and Innovation under the Future and Emerging Technologies (FET) Grant Agreement No 732482. More information can be found on the research consortium’s webpage:

The research consortium will focus on developing the technology required to scale up network-based biocomputers to a point at which they are able to compete with other alternative computing approaches such as DNA computing and quantum computing. 

In the process, they aim to attract a larger scientific and economic community that will focus on developing the technology into a viable alternative computing approach.

The Bio4Comp consortium (Photo: Teresa de Martino)
The Bio4Comp consortium (Photo: Teresa de Martino)

Project partners:

Lund University, Sweden

Linnaeus University, Sweden

Technische Universität Dresden, Germany

Molecular Sense Ltd., Oxford, U.K.

Bar-Ilan University, Israel

Fraunhofer-Gesellschaft zur Förderung der angewandten Wissenschaften e.V.



Partner 1:
Lund University, Lund, Sweden (Coordinator)
Heiner Linke, Professor of Nanophysics; Director of NanoLund
heiner [dot] linke [at] ftf [dot] lth [dot] se (heiner[dot]linke[at]ftf[dot]lth[dot]se)
+46 70 414 0245

Partner 2:
Technische Universität Dresden, Dresden, Germany
Stefan Diez, Professor for BioNanoTools,
stefan [dot] diez [at] tu-dresden [dot] de (stefan[dot]diez[at]tu-dresden[dot]de)
+49 (351) 463 43010

Franziska Clauss, Press Officer (B CUBE)
franziska [dot] clauss [at] tu-dresden [dot] de (franziska[dot]clauss[at]tu-dresden[dot]de)
+49 (0) 351 458.82065

Partner 3:
Linnaeus University, Sweden
Alf Månsson, professor of physiology
+46 70-886 62 43

Annika Sand, press officer
+46 76-830 01 05


Partner 4:
Molecular Sense Ltd., Oxford, U.K.
Dan V. Nicolau, PhD. MD.
dan [dot] nicolau [at] molecularsense [dot] com (dan[dot]nicolau[at]molecularsense[dot]com)


Partner 5:
Bar-Ilan University, Ramat Gan, Israel
Dr. Hillel Kugler
kugler [dot] hillel [at] biu [dot] ac [dot] il (kugler[dot]hillel[at]biu[dot]ac[dot]il)


Partner 6:
Fraunhofer-Gesellschaft zur Förderung der angewandten Wissenschaften e.V.
Prof. Stefan E. Schulz
stefan [dot] schulz [at] enas [dot] fraunhofer [dot] de (stefan[dot]schulz[at]enas[dot]fraunhofer[dot]de)
+49 (0)371 45001 232


Dr. Martina Vogel, Head of Marketing & Public Relations
Fraunhofer ENAS, Chemnitz
martina [dot] vogel [at] enas [dot] fraunhofer [dot] de (martina[dot]vogel[at]enas[dot]fraunhofer[dot]de)
+49 371 45001-203