“There are strong indications that this can become a valuable supplement to existing medication,” says Anders Rosengren, Docent in Metabolic Physiology at the University of Gothenburg and affiliated with the Lund University Diabetes Centre.
The publication in the journal Science Translational Medicine builds on several years’ research at Sahlgrenska Academy, University of Gothenburg, and the Faculty of Medicine at Lund University.
The objective was to find new medications against type-2 diabetes by addressing an important disease mechanism: The liver’s elevated glucose production. The classic drug metformin works by doing just that, but often causes gastric side-effects and can also not be taken when kidney function is severely reduced, which affects many with diabetes.
Lowering blood sugar
The researchers began by mapping the genetic changes in the liver in diabetes. 50 genes proved to play key roles. These were then matched against different substances in the search for compounds that could affect these particular key genes, and thereby attack the disease on a broad front.
Of 2,800 substances investigated through computer-based mathematical analyses, sulforaphane proved to have the best characteristics for the task. An antioxidant that was previously studied for the treatment of cancer and inflammatory disease, but not for diabetes was thereby identified.
Cell experiments were followed by animal studies on rats and mice with dietary-induced diabetes. The blood sugar of the animals that received sulforaphane dropped by 23 percent in four weeks, and by 24 percent in those given metformin.
“We tested removing sulforaphane from the extract and the effect disappeared. We also looked at the genes from the liver of the animals and saw that the 50 key genes had been changed in the right direction,” says Anders Rosengren.
Mice and men
With the knowledge that sulforafan does not hurt people, which was already documented, a patient study was then done with around hundred patients. All were given metformin, but the group that took sulforaphane every morning for 12 weeks had significantly lower blood sugar levels than the placebo group.
A daily dose of sulforaphane is extracted from four to five kilograms of broccoli. The plan is to have a functional food preparation out within two years. Development is taking place with Lantmännen.
“Sulforaphane targets a central mechanism in type 2 diabetes and has a mild side-effect profile. As functional food, it can reach the patients faster than a medication, and it is also an interesting concept from a diabetes perspective where diet is central,” says Anders Rosengren.
Publication: Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes
Anders Rosengren +46 (0)705 316 704
anders [dot] rosengren [at] gu [dot] se
Docent at the Institute of Neuroscience and Physiology, Sahlgrenska Academy, and the Wallenberg Centre for Molecular and Translational Medicine at the University of Gothenburg
+46 (0)703 591742
annika [dot] axelsson [at] med [dot] lu [dot] se
Doctoral student at the Faculty of Medicine, Lund University
Margareta Gustafsson Kubista +46 (0)705 301 980
margareta [dot] g [dot] kubista [at] gu [dot] se