The study, which is a follow-up of the results the researchers obtained two years ago, was carried out at Lund University and Skåne University Hospital, in collaboration with researchers in the UK.
“Now, unlike in the previous study, we have combined information about the patients’ lifestyle and clinical data from 1090 breast cancer patients with studies on breast cancer cells. The study shows that among the over 500 women treated with tamoxifen, those who had drunk at least two cups of coffee a day had only half the risk of recurrence of those who drank less coffee or none at all”, explain researchers Ann Rosendahl and Helena Jernström, who obtained the results in collaboration with Jeff Holly and his research team at University of Bristol.
“The study also shows that those who drank at least two cups of coffee a day had smaller tumours and a lower proportion of hormone-dependent tumours. We saw that this was already the case at the time of diagnosis.”
In the cell study, the researchers looked more closely at two substances that usually occur in the coffee drunk in Sweden – caffeine and caffeic acid.
“The breast cancer cells reacted to these substances, especially caffeine, with reduced cell division and increased cell death, especially in combination with tamoxifen. This shows that these substances have an effect on the breast cancer cells and turn off signalling pathways that the cancer cells require to grow.”
The researchers have demonstrated both in breast cancer patients and at cell level that coffee appears to reinforce the effect of treatment with tamoxifen, but emphasise the importance of taking prescribed medication.
“They are incredibly important, but if you like coffee and are also taking tamoxifen, there is no reason to stop drinking it. Just two cups a day is sufficient to make a difference.”
ann [dot] rosendahl [at] med [dot] lu [dot] se
+46 46 177567
helena [dot] jernstrom [at] med [dot] lu [dot] se
+46 46 177619
Publication: Caffeine and Caffeic Acid Inhibit Growth and Modify Estrogen Receptor and Insulin-like Growth Factor I Receptor Levels in Human Breast Cancer
About the study:
This study was supported by grants from the Swedish Cancer Society CAN 2011/497, the Swedish Research Council K2012-54X-22027-01-3 (PI, H. Jernström), the Faculty of Medicine at Lund University, the Unit of Nursing Research at Malmö University, the Faculty of Health and Society at Malmö University, the South Swedish Health Care Region (Region Skåne ALF), the Lund Hospital Fund, the Swedish Breast Cancer Group (BRO), the Mrs Berta Kamprad Foundation, the Crafoord Foundation, the Gunnar Nilsson Foundation, King Gustaf V's Jubilee Foundation, the Maja and Hjalmar Leander Fund, and the Royal Physiographic Society in Lund.