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Diabetes - Islet Patophysiology

Faculty of Medicine / Department of Clinical Sciences, Malmö

Phone: +46 40 39 11 57

Fax number: +46 40 39 12 22

Visiting address: CRC, Hus 91 plan 11, Jan Waldenströms gata 35, Malmö

Diabetes - Islet Patophysiology's profile in Lund University Research portal

Description

We are striving towards the identification of disease-modifying mechanisms that protect endogenous insulin release and diabetes development. Ion channels play overarching roles as sensors of cellular activity and control long-term adaptation of the endocrine pancreatic islet to the environmental demands. Our goals concern signals involved in cellular responses to beta-cell overload: 1)Role of voltage-gated Ca2+ channel subunits and Ca2+ signals for beta-cell gene expression, differentiation status, secretory capacity and diabetes 2)Role of non-voltage-gated ion channels and ligands and mechanical signals for beta-cell gene expression, differentiation status, secretory capacity and diabetes. Novel therapeutic approaches: Superparamagnetic nanoparticles as tools for targeted receptor activation and triggering of mechanosensing

Staff

A

B

  • Mohammad Barghouth

    Research project participant

    mohammad [dot] barghouth [at] med [dot] lu [dot] se

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G

J

L

R

W

Y

  • Daowei Yang

    Postdoctoral fellow

    daowei [dot] yang [at] med [dot] lu [dot] se

Z