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Estrogen and testosterone use different cellular pathways to inhibit osteoclastogenesis and bone resorption

På svenska

Author

  • H Michael
  • Pirkko Härkönen
  • H K Vaananen
  • T A Hentunen

Summary, in English

Using human peripheral blood CD14(+) osteoclast precursors, we show that testosterone directly inhibits osteoclast formation and bone resorption at physiological concentrations. Instead, estrogen has no direct effects, whereas its action seems to be mediated through osteoblasts by producing osteoprotegerin. Both estrogen and testosterone acts through their cognate receptors.

Publishing year

2005

Language

English

Pages

2224-2232

Publication/Series

Journal of Bone and Mineral Research

Volume

20

Issue

12

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Cancer and Oncology

Keywords

  • estrogen receptor
  • androgen receptor
  • estrogen
  • testosterone
  • human CD14(+) monocytes
  • bone resorption
  • osteoclast formation

Status

Published

ISBN/ISSN/Other

  • ISSN: 1523-4681