5-Hydroxytryptamine stimulates the formation of inositol phosphate in astrocytes from different regions of the brain

Summary, in English

5-Hydroxytryptamine (5-HT) stimulated the turnover of phosphoinositide in primary cultures of astroglia from the cerebral cortex, striatum, hippocampus and brain stem. Ketanserin and ritanserin, selective antagonists for the central 5-HT2 receptor, inhibited the 5-HT-stimulated formation of inositol monophosphate. In contrast, there was no statistically significant accumulation of cyclic AMP after incubation with different concentrations of 5-HT in any of the cultures studied. The results indicate that astrocytes from various regions of the brain possess 5-HT2 receptors coupled to the formation of inositol phosphates.

• Author: Elisabeth Hansson; Per Simonsson; Christer Alling
• Department/s: Clinical Chemistry, Malmö; Division of Clinical Chemistry and Pharmacology
• Publishing year: 1987
• Language: English
• Pages: 1377-1382
• Publication/Series: Neuropharmacology
• Volume: 26
• Issue: 9
• Links: http://dx.doi.org/10.1016/0028-3908(87)90102-X
• Document type: Journal article
• Publisher: Elsevier
• Topic: Pharmacology and Toxicology
• Keywords: brain stem; hippocampus; striatum; second messenger; astroglial primary culture; cerebral cortex; diacylglycerol; inositol trisphosphate; 5-HT2-receptor
• Status: Published
• Research group: Clinical Chemistry, Malmö
• ISBN/ISSN/Other: ISSN: 1873-7064