The cerebellar microcircuit as an adaptive filter: experimental and computational evidence

Summary, in English

Initial investigations of the cerebellar microcircuit inspired the Marr-Albus theoretical framework of cerebellar function. We review recent developments in the experimental understanding of cerebellar microcircuit characteristics and in the computational analysis of Marr-Albus models. We conclude that many Marr-Albus models are in effect adaptive filters, and that evidence for symmetrical long-term potentiation and long-term depression, interneuron plasticity, silent parallel fibre synapses and recurrent mossy fibre connectivity is strikingly congruent with predictions from adaptive-filter models of cerebellar function. This congruence suggests that insights from adaptive-filter theory might help to address outstanding issues of cerebellar function, including both microcircuit processing and extra-cerebellar connectivity.

• Author: Paul Dean; John Porrill; Carl-Fredrik Ekerot; Henrik Jörntell
• Department/s: Neural Basis of Sensorimotor Control; NanoLund: Centre for Nanoscience
• Publishing year: 2010
• Language: English
• Pages: 30-43
• Publication/Series: Nature Reviews Neuroscience
• Volume: 11
• Issue: 1
• Links: http://dx.doi.org/10.1038/nrn2756
• Document type: Journal article review
• Publisher: Nature Publishing Group
• Topic: Neurosciences
• Status: Published
• Research group: Neural Basis of Sensorimotor Control
• ISBN/ISSN/Other: ISSN: 1471-003X