Development of wide-pore CLEAR supports for applications involving biological macromolecules.
Author
Summary, in English
The CLEAR supports were originally developed for solid-phase synthesis. In this study, two wide-pore versions of the resins were prepared by radical suspension polymerization using toluene as the porogen. Trimethylolpropane ethoxylate (14/3 EO/OH) triacrylate was used as the cross-linking agent. Resins of two different porosities were synthesized. The permeability to biological macromolecules was investigated by size exclusion chromatography, using the resin beads as the stationary phase. One of the resins was able to retard thyroglobulin (669 kDa) while the other, prepared with a lower amount of porogen, showed a lower fractionation range (1-60 kDa).
Department/s
Publishing year
2001
Language
English
Pages
381-387
Publication/Series
Polymer Bulletin
Volume
46
Issue
5
Document type
Journal article
Publisher
Springer
Topic
- Pharmacology and Toxicology
Status
Published
Research group
- Nanomedicine and Biomaterials
ISBN/ISSN/Other
- ISSN: 0170-0839