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Changes in transport functions of isolated rabbit choroid plexus under the influence of oestrogen and progesterone

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Author

  • M Lindvall-Axelsson
  • Christer Owman

Summary, in English

Isolated choroid plexuses from rabbits were used to determine uptake and accumulation of 10(-5) M radiolabelled choline (expressed as tissue/medium ratio) and the activities of various types of ATPases (based on ouabain inhibition and bicarbonate stimulation) following pre-treatment of the animals with 0.5 mg kg-1 17-beta-oestradiol, alone or in combination with 2 mg kg-1 progesterone. The combined treatment reduced the choline uptake by 35% and also lowered the activity of Na+,K+-ATPase by 31%, without influencing tissue wet weight. The reduction in HCO3-ATPase was smaller and not statistically significant. There was a tendency also for oestrogen alone to lower these activities, but only by less than 20%. The Ca2+,Mg2+-ATPase activity was not significantly affected by any of the hormones.

Department/s

  • Drug Target Discovery

Publishing year

1989

Language

English

Pages

107-111

Publication/Series

Acta Physiologica Scandinavica

Volume

136

Issue

1

Document type

Journal article

Publisher

Wiley-Blackwell

Topic

  • Pharmacology and Toxicology

Status

Published

Research group

  • Drug Target Discovery

ISBN/ISSN/Other

  • ISSN: 0001-6772