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Intake levels of dietary long-chain PUFAs modify the association between genetic variation in FADS and LDL-C

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Author

Summary, in English

Polymorphisms of the FA desaturase (FADS) gene cluster have been associated with LDL, HDL, and triglyceride concentrations. Because FADS converts alpha-linolenic acid (ALA) and linoleic acid into PUFAs, we investigated the interaction between different PUFA intakes and the FADS polymorphism rs174547 (T>C) on fasting blood lipid and lipoprotein concentrations. We included 4,635 individuals (60% females, 45-68 years) from the Swedish population-based Malmo Diet and Cancer cohort. Dietary intakes were assessed by a modified diet history method including 7-day registration of cooked meals. The C-allele of rs174547 was associated with lower LDL concentration (P = 0.03). We observed significant interaction between rs174547 and long-chain omega-3 PUFA intakes on LDL (P = 0.01); the C-allele was only associated with lower LDL among individuals in the lowest tertile of long-chain omega-3 PUFA intakes (P < 0.001). In addition, significant interaction was observed between rs174547 and the ratio of ALA and linoleic FA intakes on HDL (P = 0.03). However, no significant associations between the C-allele and HDL were detected within the intake tertiles of the ratio. Our findings suggest that dietary intake levels of different PUFAs modify the associated effect of genetic variation in FADS on LDL and HDL.-Hellstrand, S., E. Sonestedt, U. Ericson, B. Gullberg, E. Wirfalt, B. Hedblad, and M. Orho-Melander. Intake levels of dietary PUFAs modify the association between genetic variation in FADS and LDL-C. J. Lipid Res. 2012. 53: 1183-1189.

Publishing year

2012

Language

English

Pages

1183-1189

Publication/Series

Journal of Lipid Research

Volume

53

Issue

6

Document type

Journal article

Publisher

American Society for Biochemistry and Molecular Biology

Topic

  • Endocrinology and Diabetes
  • Cardiac and Cardiovascular Systems
  • Nutrition and Dietetics

Keywords

  • diet
  • fatty acid desaturase
  • polyunsaturated fatty acids
  • cholesterol
  • cohort
  • epidemiology
  • low density lipoprotein cholesterol

Status

Published

Project

  • Interaction between dietary factors and genetic risk for lipoprotein traits and cardiovascular disease

Research group

  • Diabetes - Cardiovascular Disease
  • Nutrition Epidemiology
  • Cardiovascular Research - Epidemiology

ISBN/ISSN/Other

  • ISSN: 1539-7262