Proteomic profiling of plasma in Huntington's disease reveals neuroinflammatory activation and biomarker candidates

Summary, in English

Huntington's disease (HD) causes widespread CNS changes and systemic abnormalities including endocrine and immune dysfunction. HD biomarkers are needed to power clinical trials of potential treatments. We used multiplatform proteomic profiling to reveal plasma changes with HD progression. Proteins of interest were evaluated using immunoblotting and ELISA in plasma from 2 populations, CSF and R6/2 mice. The identified proteins demonstrate neuroinflammation in HD and warrant further investigation as possible biomarkers.

• Author: Annette Dalrymple; Edward J. Wild; Richard Joubert; Kirupa Sathasivam; Maria Bjorkqvist; Åsa Petersén; Graham S. Jackson; Jeremy D. Isaacs; Mark Kristiansen; Gillian P. Bates; Blair R. Leavitt; Geoff Keir; Malcolm Ward; Sarah J. Tabrizi
• Department/s: Translational Neuroendocrinology
• Publishing year: 2007
• Language: English
• Pages: 2833-2840
• Publication/Series: Journal of Proteome Research
• Volume: 6
• Issue: 7
• Links: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17552550&dopt=Abstract; http://dx.doi.org/10.1021/pr0700753
• Document type: Journal article
• Publisher: The American Chemical Society (ACS)
• Topic: Basic Medicine
• Keywords: electrophoresis; 2D; proteomics; neuroinflammation; Huntington's disease; plasma; LC/MS/MS; MALDI-TOF; ELISA; biomarkers
• Status: Published
• Research group: Translational Neuroendocrinology
• ISBN/ISSN/Other: ISSN: 1535-3893