Skeletal muscle atrophy in r6/2 mice - altered circulating skeletal muscle markers and gene expression profile changes.

Summary, in English

In addition to classical neurological symptoms, Huntington's disease (HD) is complicated by peripheral pathology, including progressive skeletal muscle wasting, and common skeletal muscle gene expression changes have been shown in HD mice and human HD.

• Author: Anna Magnusson-Lind; Marcus Davidsson; Edina Silajdzic; Christian Hansen; Andy McCourt; Sarah J Tabrizi; Maria Björkqvist
• Department/s: Biomarkers in Brain Disease; Molecular Neurobiology; Neural Plasticity and Repair; MultiPark: Multidisciplinary research focused on Parkinson´s disease
• Publishing year: 2014
• Language: English
• Pages: 13-24
• Publication/Series: Journal of Huntington's disease
• Volume: 3
• Issue: 1
• Links: http://www.ncbi.nlm.nih.gov/pubmed/25062762?dopt=Abstract; http://dx.doi.org/10.3233/JHD-130075
• Document type: Journal article
• Publisher: IOS Press
• Topic: Neurology
• Status: Published
• Research group: Biomarkers in Brain Disease; Molecular Neurobiology; Neural Plasticity and Repair
• ISBN/ISSN/Other: ISSN: 1879-6397