Ligand-induced tyrosine phosphorylation of cysteinyl leukotriene receptor 1 triggers internalization and signaling in intestinal epithelial cells.

Summary, in English

Leukotriene D(4) (LTD(4)) belongs to the bioactive lipid group known as eicosanoids and has implications in pathological processes such as inflammation and cancer. Leukotriene D(4) exerts its effects mainly through two different G-protein-coupled receptors, CysLT(1) and CysLT(2). The high affinity LTD(4) receptor CysLT(1)R exhibits tumor-promoting properties by triggering cell proliferation, survival, and migration in intestinal epithelial cells. In addition, increased expression and nuclear localization of CysLT(1)R correlates with a poorer prognosis for patients with colon cancer.

• Author: Ladan Parhamifar; Wondossen Sime; Yuliana Yudina; Frederik Vilhardt; Matthias Mörgelin; Anita Sjölander
• Department/s: Cell Pathology, Malmö; Infection Medicine (BMC)
• Publishing year: 2010
• Language: English
• Publication/Series: PLoS ONE
• Volume: 5
• Issue: 12
• Full text: - 1 MB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/21203429?dopt=Abstract; http://dx.doi.org/10.1371/journal.pone.0014439
• Document type: Journal article
• Publisher: Public Library of Science (PLoS)
• Topic: Infectious Medicine; Cancer and Oncology
• Status: Published
• Research group: Cell Pathology, Malmö
• ISBN/ISSN/Other: ISSN: 1932-6203