Serotonin-dopamine interaction in the induction and maintenance of L-DOPA-induced dyskinesias
Author
Summary, in English
Appearance of dyskinesia is a common problem of long-term Levodopa (L-DOPA) treatment in Parkinson's disease (PD) patients and represents a major limitation for the pharmacological management of the motor symptoms in the advanced stages of disease. An increasing body of evidence points to dopamine released as a false neurotransmitter from the striatal serotonin terminals as the main pre-synaptic determinant of L-DOPA-induced dyskinesia. Here we review the animal experimental and human clinical data in support of this view, which point to the serotonin system as a promising target for anti-dyskinetic therapy in PD patients under L-DOPA medication.
Publishing year
2008
Language
English
Pages
465-478
Publication/Series
Progress in Brain Research
Volume
172
Links
Document type
Journal article
Publisher
Elsevier
Topic
- Neurosciences
Keywords
- Animals
- Clinical Trials as Topic
- Dopamine
- Dyskinesia, Drug-Induced
- Humans
- Levodopa
- Parkinson Disease
- Parkinsonian Disorders
- Presynaptic Terminals
- Protein Isoforms
- Receptors, Dopamine
- Receptors, Serotonin
- Serotonin
- Journal Article
- Research Support, Non-U.S. Gov't
- Review
Status
Published
Research group
- Neurobiology
- Brain Repair and Imaging in Neural Systems (BRAINS)
ISBN/ISSN/Other
- ISSN: 1875-7855