Healthy Satiety Effects of Paleolithic diet on Satiety and Risk factors for Cardiovascular disease
Author
Summary, in English
In paper I we reviewed evidence from epidemiology and evolutionary biology for a possible maladaptation of human satiety hormone leptin to agrarian diet. We found that leptin resistance hypothetically may be a sign of maladaptation to dietary cereals as staple food, and that lectins could be a cereal constituent with sufficient properties to cause leptin resistance.
In paper II we experimentally studied the long-term effect of a Paleolithic diet compared to a cereal-based diet on risk factors for cardiovascular disease in domestic pigs. We found that a Paleolithic diet conferred higher insulin sensitivity, lower C-reactive protein and lower blood pressure than a cereal-based diet.
In paper III and IV we experimentally studied the effect of a Paleolithic diet compared to a Mediterranean-like diet on risk factors for cardiovascular disease, satiety and leptin in individuals with ischaemic heart disease and either glucose intolerance or type 2 diabetes. Paper III showed that a Paleolithic diet improved glucose tolerance more than a Mediterranean-like diet, and paper IV showed that a Paleolithic diet was more satiating per calorie than a Mediterranean-like diet.
In conclusion, we have found beneficial effects of a Paleolithic diet on risk factors for cardiovascular disease and satiety.
Department/s
Publishing year
2007
Language
English
Publication/Series
Faculty of Medicine Doctoral Dissertation Series
Volume
2007:145
Full text
Document type
Dissertation
Publisher
Division of Family Medicine Department of Clinical Sciences Lund University Sweden
Topic
- Other Clinical Medicine
Keywords
- Cardiovascular system
- diabetologi
- sekretion
- Endokrinologi
- Cardiovascular Disease
- Paleolithic Diet
- Satiety
- Endocrinology
- diabetology
- secreting systems
- Kardiovaskulära systemet
Status
Published
Supervisor
- Staffan Lindeberg
ISBN/ISSN/Other
- ISSN: 1652-8220
- ISBN: 978-91-85897-23-0
Defence date
23 November 2007
Defence time
13:00
Defence place
Föreläsningssal 3, Lund University Hospital, Lund, Sweden
Opponent
- Mai-Lis Hellénius (Professor)