The nasal mucosa contains a large diversity of human papillomavirus from the Beta- and Gammapapillomavirus genera.

Summary, in English

Background. Human papillomavirus (HPV) types from the Beta- and Gammapapillomavirus genera are common at cutaneous sites. The aim of this study was to analyze the prevalence of these HPV types in oral and nasal samples.Methods. Nasal and oral samples were taken from 312 volunteers of Danish health-care staff (240 women and 72 males, with mean age of 42 years). Of these 311 oral and 304 nasal samples were eligible for HPV DNA analysis.HPV types were detected by the use of PCR with MGP- and FAP-primers and identified by Luminex (MGP), and direct sequencing or cloning prior to sequencing (FAP).Results. HPV DNA was detected in 6% of the oral samples and 50% of the nasal samples. A large diversity of 75 HPV types/putative HPV types was identified. HPV types within genus Alpha-, Beta- and Gammapapillomaviruses were detected in 3%, 31%, and 23% of the nasal samples, respectively. A putative subtype of HPV76, originally isolated from a feline oral SCC, was detected in seven nasal samples.Conclusion. A large spectrum of HPV types from Beta- and Gammapapillomavirus have tropism for the nasal mucosa. The implication of the relatively high prevalence of these viruses in the nasal mucosa is unknown.

• Author: Ola Forslund; Hanna K Johansson; Klaus Gregaard Madsen; Kristian Kofoed
• Department/s: Clinical Microbiology, Malmö; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publishing year: 2013
• Language: English
• Pages: 1335-1341
• Publication/Series: Journal of Infectious Diseases
• Volume: 208
• Issue: 8
• Links: http://www.ncbi.nlm.nih.gov/pubmed/23878325?dopt=Abstract; http://dx.doi.org/10.1093/infdis/jit326
• Document type: Journal article
• Publisher: Oxford University Press
• Topic: Infectious Medicine
• Status: Published
• Research group: Clinical Microbiology, Malmö
• ISBN/ISSN/Other: ISSN: 1537-6613