Distribution of different fibre types in human skeletal muscles. A statistical and computational model for the study of fibre type grouping and early diagnosis of skeletal muscle fibre denervation and reinnervation
Author
Summary, in English
To define fibre type grouping in terms of random and non-random arrangements of the two fibre types, type 1 (ST) and type 2 (FT), we adopted the measure of counting the number of "enclosed fibres". The statistical properties of the number of enclosed fibres, and the number and size of groups of enclosed fibres were studied in computer-simulated muscle cross-sections, using a model based upon hexagonal-shaped fibres. The effects on the results of differences in the sizes of the muscle fibres were considered. The applicability of the model, and the derived results and methods of analysis were tested on 10 samples from a cross-section of a whole human muscle. The results show that the model can be applied to various shapes and sizes of muscle samples and various sizes of muscle fibres. The number of enclosed fibres within a muscle sample is the best of the three measures of non-randomness considered. A test is also described for assessing whether or not the observed number of enclosed fibres is random at a given significance level.
Department/s
Publishing year
1983
Language
English
Pages
301-314
Publication/Series
Journal of the Neurological Sciences
Volume
61
Issue
3
Document type
Journal article
Publisher
Elsevier
Topic
- Surgery
- Neurology
Keywords
- Diagnosis
- computer assisted
- Histocytochemistry
- Microcomputers
- Muscle denervation
- Muscles
- Needle biopsy
- Nerve degeneration
- Nerve regeneration
Status
Published
ISBN/ISSN/Other
- ISSN: 1878-5883