Five homologous repeats of the protein G-related protein MIG cooperate in binding to goat immunoglobulin G

Summary, in English

Protein MIG, from Streptococcus dysgalactiae, binds alpha2-macroglobulin and immunoglobulin G (IgG). MIG-derived fusion proteins with one to five IgG-binding repeats differed up to 72,000- fold in avidity for goat IgG, indicating a considerable cooperativity of the repeats. Significant sequence variation in the IgG-binding repeats was recognized. Protein MIG interacted with goat IgG1 via both the Fc and Fab parts.

• Author: J Vasi; J Svensson; Inga-Maria Frick; H P Muller
• Department/s: Infection Medicine (BMC)
• Publishing year: 1999
• Language: English
• Pages: 413-416
• Publication/Series: Infection and Immunity
• Volume: 67
• Issue: 1
• Links: http://iai.highwire.org/cgi/content/full/67/1/413
• Document type: Journal article
• Publisher: American Society for Microbiology
• Topic: Infectious Medicine
• Status: Published
• ISBN/ISSN/Other: ISSN: 1098-5522