Oxidized Dextran as Crosslinker for Chitosan Cryogel Scaffolds and Formation of Polyelectrolyte Complexes between Chitosan and Gelatin.
Author
Summary, in English
Macroporous scaffolds composed of chitosan and using oxidized dextran as a crosslinker are produced through cryogelation. Introducing gelatin as a third component into the structure results in the formation of mesopores in the pore walls, which are not seen if gelatin is excluded. The mesoporous structure is explained by the formation of polyelectrolyte complexes between chitosan and gelatin before crosslinking takes place. The scaffolds exhibit highly elastic properties withstanding compressions up to 60%. The in vitro biocompatibility of the cryogels is evaluated using fibroblasts from a mouse cell line (L929) and it is seen that the cells adhere and proliferate on the scaffolds. The mesoporous structure seems to have a positive effect on proliferation.
Department/s
Publishing year
2012
Language
English
Pages
1090-1099
Publication/Series
Macromolecular Bioscience
Volume
12
Issue
8
Links
Document type
Journal article
Publisher
John Wiley & Sons Inc.
Topic
- Bio Materials
Status
Published
Research group
- Muscle Biology
ISBN/ISSN/Other
- ISSN: 1616-5195