Buserelin treatment to rats causes enteric neurodegeneration with moderate effects on CRF-immunoreactive neurons and Enterobacteriaceae in colon, and in acetylcholine-mediated permeability in ileum.
Author
Summary, in English
The gonadotropin-releasing hormone (GnRH) analog buserelin causes enteric neuronal loss. Acute stress or injection of corticotropin-releasing factor (CRF) affects motility, secretion, and barrier function of the gastrointestinal tract. The aim of the study was to characterize the CRF immunoreactivity in enteric neurons after buserelin treatment, and to evaluate possible effects of enteric neuropathy on gut microbiota, intestinal permeability, and stress response behavior.
Department/s
- Neurogastroenterology
- Division of Food and Pharma
- Clinical Coagulation, Malmö
- Gastroenterology
- Chronic Inflammatory and Degenerative Diseases Research Unit
- Internal Medicine - Epidemiology
Publishing year
2015
Language
English
Publication/Series
BMC Research Notes
Volume
8
Issue
1
Links
Document type
Journal article
Publisher
BioMed Central (BMC)
Topic
- Gastroenterology and Hepatology
Status
Published
Research group
- Neurogastroenterology
- Clinical Coagulation, Malmö
- Gastroenterology
- Chronic Inflammatory and Degenerative Diseases Research Unit
- Internal Medicine - Epidemiology
ISBN/ISSN/Other
- ISSN: 1756-0500