Detailed gene dose analysis reveals recurrent focal gene deletions in pediatric B-cell precursor acute lymphoblastic leukemia
Author
Summary, in English
To identify copy number alterations (CNAs) in pediatric B-cell precursor acute lymphoblastic leukemia (BCP ALL), array comparative genomic hybridization was performed on 50 cases; detected CNAs were validated in a cohort of 191 cases analyzed by single nucleotide polymorphism arrays. Apart from CNAs involving leukemia-associated genes, recurrent deletions targeting genes not previously implicated in BCP ALL, e.g. INIP, IRF1 and PDE4B, were identified. Deletions of the DNA repair gene INIP were exclusively found in cases with t(12;21), and deletions of SH2B3 were associated with intrachromosomal amplification of chromosome 21 (p
Department/s
- Division of Clinical Genetics
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
Publishing year
2016-04-18
Language
English
Pages
2161-2170
Publication/Series
Leukemia & Lymphoma
Volume
57
Issue
9
Document type
Journal article
Publisher
Taylor & Francis
Topic
- Hematology
- Medical Genetics
Keywords
- B-Other
- CNA
- copy number
- deletion
- pediatric ALL
Status
Published
ISBN/ISSN/Other
- ISSN: 1042-8194