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Synthesis of the Bioactive Benzochromenes Pulchrol and Pulchral, Metabolites of Bourreria pulchra

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Author

Summary, in English

The parasites Leshmania mexicana and Trypanosoma cruzi cause serious health problems, and few efficient treatments are available. Recently, the two benzochromenes pulchrol (1) and pulchral (2) were reported from the roots of Bourreria pulchra, and especially 1 but also 2 was found to be active towards the parasites. In this paper, we present a total synthesis of 1 and 2 to facilitate their biological evaluation. The synthesis is mild, short, and high yielding and suitable for a structure-activity relationship study.

Publishing year

2014

Language

English

Pages

1594-1596

Publication/Series

European Journal of Organic Chemistry

Volume

2014

Issue

8

Document type

Journal article

Publisher

John Wiley & Sons Inc.

Topic

  • Chemical Sciences

Keywords

  • Total synthesis
  • Natural products
  • Bioactive metabolites
  • Cross-coupling
  • Oxygen heterocycles

Status

Published

ISBN/ISSN/Other

  • ISSN: 1434-193X