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SOCS6 (suppressor of cytokine signaling 6)

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Author

Summary, in English

The suppressor of cytokine signaling (SOCS) family of proteins are well known negative regulators of cytokine receptors signaling consisting of eight structurally similar proteins, SOCS1-7 and CIS. A key feature of this family of proteins is the presence of two structural motifs: a centrally located SH2 domain and a SOCS box in the C-terminus. The SOCS box mediates the interaction with the Elongins B and C complex while an additional motif mediates its interaction with Cullin 5 to assemble a Cullin/Ring ubiquitin ligase. In this complex SOCS6 acts as a substrate recognition subunit through interactions mediated by the N-terminus and the SH2 domain. SOCS6 interacts with tyrosine kinase receptors FLT3 and c-KIT and modulate their ubiquitination and function.

Department/s

Publishing year

2015

Language

English

Pages

50-52

Publication/Series

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Volume

19

Issue

1

Document type

Journal article review

Publisher

ARMGHM / NIST - CNRS

Topic

  • Cancer and Oncology

Keywords

  • CIS4
  • SSI4
  • CIS-4
  • SOCS4
  • STAI4
  • SOCS-4
  • SOCS-6
  • STATI4
  • HSPC060.

Status

Published

ISBN/ISSN/Other

  • ISSN: 1768-3262