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Tumour biology of a breast cancer at least partly reflects the biology of the tissue/epithelial cell of origin at the time of initiation - a hypothesis

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Author

  • Håkan Olsson

Summary, in English

A hypothesis is presented suggesting that initiation of breast epithelial cell freezes the cell at least partly according to the development/differention of cell at the time of initiation. Tumour biology will mimic the physiology of normal cell development at the time of initiation and this is preserved at least partly onwards. Also preferentially, tumours will develop from the cell type that is proliferating at the time of initiation. This may explain the overrepresentation of different types of histology in breast cancer in relation to age of the woman. The development of each tumour may follow at least partly a distinct pathway of evolution.

Publishing year

2000-11-30

Language

English

Pages

345-350

Publication/Series

Journal of Steroid Biochemistry and Molecular Biology

Volume

74

Issue

5

Document type

Journal article

Publisher

Elsevier

Topic

  • Cancer and Oncology

Keywords

  • Age Factors
  • Age of Onset
  • BRCA2 Protein
  • Breast
  • Breast Neoplasms
  • Cell Differentiation
  • Epithelial Cells
  • Female
  • Genes, BRCA1
  • Genetic Predisposition to Disease
  • Humans
  • Models, Biological
  • Neoplasm Proteins
  • Prognosis
  • Risk Factors
  • Transcription Factors

Status

Published

Research group

  • Lund Melanoma Study Group

ISBN/ISSN/Other

  • ISSN: 0960-0760