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Type I interferon signaling in dendritic cells stimulates the development of lymph-node-resident T follicular helper cells.

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Author

Summary, in English

T follicular helper (Tfh) cells represent a recently defined CD4(+) T cell subset characterized by the expression of the chemokine receptor CXCR5 and an enhanced ability to support B cells to mount antibody responses. Here, we demonstrate that lymph-node-resident CXCR5(+) Tfh cells and gut-homing integrin alpha(4)beta(7)-expressing T helper cells are generated as separate subsets in the gut-draining mesenteric lymph nodes. Type I interferon signaling in dendritic cells and in nonhematopoietic cells selectively stimulates Tfh cell development in response to antigen in conjunction with Toll-like receptor (TLR)3 or TLR4 agonists. Consistent with this, the ability of dendritic cells to produce the cytokine IL-6, required for in vivo Tfh differentiation, and antibody affinity maturation are both reduced in absence of type I interferon signaling. Thus, our results identify type I interferon as a natural adjuvant that selectively supports the generation of lymph node resident Tfh cells.

Department/s

  • Immunology

Publishing year

2009

Language

English

Pages

491-501

Publication/Series

Immunity

Volume

31

Issue

3

Document type

Journal article

Publisher

Cell Press

Topic

  • Immunology in the medical area

Keywords

  • Helper-Inducer: metabolism
  • T-Lymphocytes
  • Receptor
  • Interferon alpha-beta: immunology
  • Receptors
  • CXCR5: metabolism
  • Helper-Inducer: cytology
  • Helper-Inducer: immunology
  • Interferon alpha-beta: genetics
  • Interferon alpha-beta: deficiency
  • Lymph Nodes: metabolism
  • Lymph Nodes: immunology
  • Lymph Nodes: cytology
  • Interleukin-6: biosynthesis
  • Interferon Type I: immunology
  • Integrins: metabolism
  • CD11c: immunology
  • Antigens
  • Dendritic Cells: immunology

Status

Published

Research group

  • Immunology

ISBN/ISSN/Other

  • ISSN: 1074-7613