Hypoxic conditions induce a cancer-like phenotype in human breast epithelial cells.

Summary, in English

Solid tumors are less oxygenated than their tissue of origin. Low intra-tumor oxygen levels are associated with worse outcome, increased metastatic potential and immature phenotype in breast cancer. We have reported that tumor hypoxia correlates to low differentiation status in breast cancer. Less is known about effects of hypoxia on non-malignant cells. Here we address whether hypoxia influences the differentiation stage of non-malignant breast epithelial cells and potentially have bearing on early stages of tumorigenesis.

• Author: Marica Vaapil; Karolina Helczynska; René Villadsen; Ole W Petersen; Elisabet Johansson; Siv Beckman; Christer Larsson; Sven Påhlman; Annika Jögi
• Department/s: Department of Translational Medicine; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publishing year: 2012
• Language: English
• Publication/Series: PLoS ONE
• Volume: 7
• Issue: 9
• Full text: - 921 kB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/23029547?dopt=Abstract; http://dx.doi.org/10.1371/journal.pone.0046543
• Document type: Journal article
• Publisher: Public Library of Science (PLoS)
• Topic: Cancer and Oncology
• Keywords: hypoxia; Breast cancer; differentiation; epithelial cells
• Status: Published
• ISBN/ISSN/Other: ISSN: 1932-6203