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Serum levels of a subset of cytokines show high interindividual variability and are not altered in rats transgenic for Huntington´s disease.

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Author

  • Huu Phuc Nguyen
  • Maria Björkqvist
  • Felix J Bode
  • Michael Stephan
  • Stephan von Hörsten

Summary, in English

To evaluate whether cytokines are altered in peripheral blood of rats transgenic for the human Huntington´s disease mutation we investigated serum levels of GRO/KC, IL-1β, IL-13 and TNF-α at a symptomatic stage at 12 months of age. Overall serum levels of these cytokines were not significantly changed between transgenic HD rats and controls. Moreover, we observed a high interindividual variability. Our results indicate that these cytokines will be difficult to pursue as biomarkers in at least this rat model of HD.

Publishing year

2010

Language

English

Publication/Series

PLoS Currents

Volume

2

Document type

Journal article

Publisher

Public Library of Science (PLoS)

Topic

  • Neurosciences

Status

Published

ISBN/ISSN/Other

  • ISSN: 2157-3999