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No diagnostic value of plasma clusterin in Alzheimer's disease.

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Author

Summary, in English

There is an urgent need for biomarkers to enable early diagnosis of Alzheimer's disease (AD). It has recently been shown that a variant within the clusterin gene is associated with increased risk of AD and plasma levels of clusterin have been found to be associated with the risk of AD. We, therefore, investigated the diagnostic value of clusterin by quantifying clusterin using an ELISA in plasma from 171 controls, 127 patients with AD, 82 patients with other dementias and 30 patients with depression. We observed similar plasma clusterin levels in controls, AD patients and patients with other dementias, suggesting that plasma clusterin levels have no diagnostic value for AD. There was a slight, but significant, increase in plasma clusterin in patients with depression compared to all other groups tested, which may warrant further investigation.

Publishing year

2012

Language

English

Publication/Series

PLoS ONE

Volume

7

Issue

11

Document type

Journal article

Publisher

Public Library of Science (PLoS)

Topic

  • Neurology
  • Basic Medicine

Status

Published

Research group

  • Biomarkers in Brain Disease
  • Clinical Memory Research
  • Translational Neuroendocrinology

ISBN/ISSN/Other

  • ISSN: 1932-6203