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Endothelin-1 Reduces Microvascular Fluid Permeability through Secondary Release of Prostacyclin in Cat Skeletal Muscle.

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Author

Summary, in English

The aim of the study was to analyze effects of various plasma concentrations of the vasoconstrictor endothelin-1 on microvascular fluid permeability and on transcapillary fluid exchange. We also analyzed whether the permeability-reducing substance prostacyclin is involved in the permeability effects of endothelin-1, as prostacylin is suggested to be released via ET(B) receptor stimulation. The study was performed on an autoperfused cat calf muscle preparation, and a capillary filtration coefficient (CFC) technique was used to estimate variations in microvascular fluid permeability (conductivity). Intraarterial infusion of endothelin-1 in low doses (5 and 10 ng/min/100 g muscle) caused transcapillary absorption, whereas higher doses (20-40 ng/min/100 g) induced filtration despite further vasoconstriction. Low-dose endothelin-1 had no significant effect on CFC, while CFC was reduced to at most 55% of baseline at higher doses (P < 0.01). Simultaneous local intraarterial infusion of the prostacyclin synthesis inhibitor tranylcypromine restored CFC to 114% of baseline (P < 0.01) and further increased vascular resistance. A low, nonvasodilator dose of prostacyclin given intravenously counteracted the tranylcypromine effect on CFC. The decreased CFC induced by a high dose of endothelin-1 was counteracted by the ET(B) receptor antagonist BQ-788 with no change in vascular resistance (P < 0.05). We conclude that the decreased CFC following high doses of endothelin-1 can be attributed to a decrease in microvascular hydraulic conductivity, mediated by secondary release of prostacylin via stimulation of the ET(B) receptor. Endothelin-1 may induce edema through postcapillary vasoconstriction. (c)2001 Elsevier Science.

Publishing year

2002

Language

English

Pages

50-60

Publication/Series

Microvascular Research

Volume

63

Issue

1

Document type

Journal article

Publisher

Academic Press

Topic

  • Basic Medicine

Keywords

  • Epoprostenol : antagonists & inhibitors : metabolism
  • Male
  • Microcirculation : metabolism
  • Muscle Skeletal : cytology : metabolism
  • Receptors Endothelin metabolism
  • Support Non-U.S. Gov't
  • Tranylcypromine : pharmacology
  • Time Factors
  • Endothelin-1 : biosynthesis
  • Dose-Response Relationship Drug
  • Cats
  • Capillary Permeability
  • Arteries : metabolism
  • Capillaries : metabolism
  • Animal

Status

Published

ISBN/ISSN/Other

  • ISSN: 1095-9319