Auditory event-related potentials and cognitive outcome after very preterm birth
Author
Summary, in English
AERPs at preschool age in children born very preterm showed abnormalities in comparison with more maturely born children. Similar abnormalities have been reported in full-term children with cognitive and behavioral problems (especially smaller amplitudes of early AERP deflections). Within the very preterm group, faster early sound processing was associated with better psychological test results, and sound differentiation was different between children with normal and abnormal test results. We showed that immaturity at birth, neonatal morbidity, and neonatal brain damage had an impact on different aspects of auditory processing, and that this impact still was present at 5 years of age. In the infants investigated at term age, we showed that later sound processing as well as sound differentiation has a high correlation with both cognitive and neurological outcome. Neonatal morbidity rather than prematurity itself had a strong impact on sound differentiation. AERPs showed stronger associations with outcome than brain volumes.
We conclude that AERPs are promising as a prognostic tool for outcome in very preterm infants. They can add considerably to established anatomical methods such as MRI. However, more research is needed before AERPs can be applicable in clinical praxis.
Department/s
Publishing year
2015
Language
English
Publication/Series
Lund University Faculty of Medicine Doctoral Dissertation Series
Volume
2015:30
Full text
- Available as PDF - 24 MB
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Document type
Dissertation
Publisher
Lund University: Faculty of Medicine
Topic
- Pediatrics
Keywords
- Preterm
- Event-related potentials
- Mismatch negativity
- Magnetic resonance imaging
- developmental outcome
Status
Published
Supervisor
- Vineta Fellman
- Elna-Marie Larsson
- Minna Huotilainen
ISBN/ISSN/Other
- ISSN: 1652-8220
- ISBN: 978-91-7619-109-5
Defence date
28 March 2015
Defence time
10:00
Defence place
Belfragesalen, BMC D15, Klinikgatan 32, Lund
Opponent
- Michael K Georgieff (Professor)