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Origins of substance P- and calcitonin gene-related peptide-containing nerves in the internal carotid artery of rat

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Author

  • Jan Erik Hardebo
  • Norihiro Suzuki
  • Christer Owman

Summary, in English

An aggregation of substance P (SP)- and calcitonin gene-related peptide (CGRP)-containing nerve cells (internal carotid mini-ganglion) is described at the junction between the greater superficial petrosal nerve and the internal carotid nerve close to the internal carotid artery. A retrograde tracer dye technique demonstrates that this ganglion and the trigeminal and superior vagal ganglia supply the internal carotid artery with SP/CGRP fibers at, above and below this level, respectively. Implications of this finding for cranial painful syndromes in man are discussed.

Department/s

Publishing year

1989

Language

English

Pages

39-45

Publication/Series

Neuroscience Letters

Volume

101

Issue

1

Document type

Journal article

Publisher

Elsevier

Topic

  • Neurosciences

Keywords

  • Sensory nerve fiber
  • Sensory ganglia
  • Peptide
  • Substance P
  • Calcitonin gene-related peptide
  • Immunohistochemistry

Status

Published

Research group

  • Drug Target Discovery

ISBN/ISSN/Other

  • ISSN: 0304-3940