Differentiation of the Gastric Mucosa I. Role of histamine in control of function and integrity of oxyntic mucosa: understanding gastric physiology through disruption of targeted genes
Author
Summary, in English
Many physiological functions of the stomach depend on an intact mucosal integrity; function reflects structure and vice versa. Histamine in the stomach is synthesized by histidine decarboxylase (HDC), stored in enterochromaffin-like (ECL) cells, and released in response to gastrin, acting on CCK2 receptors on the ECL cells. Mobilized ECL cell histamine stimulates histamine H-2 receptors on the parietal cells, resulting in acid secretion. The parietal cells express H-2, M-3, and CCK2 receptors and somatostatin sst(2) receptors. This review discusses the consequences of disrupting genes that are important for ECL cell histamine release and synthesis (HDC, gastrin, and CCK2 receptor genes) and genes that are important for "cross-talk" between H-2 receptors and other receptors on the parietal cell (CCK2, M-3, and sst(2) receptors). Such analysis may provide insight into the functional significance of gastric histamine.
Department/s
- Drug Target Discovery
Publishing year
2006
Language
English
Pages
539-544
Publication/Series
American Journal of Physiology: Gastrointestinal and Liver Physiology
Volume
291
Issue
4
Document type
Journal article
Publisher
American Physiological Society
Topic
- Physiology
Keywords
- gastric acid secretion
- knockout mice
- oxyntic mucosal proliferation
- gastrin
- and differentiation
- gastrin receptor
- histamine
Status
Published
Research group
- Drug Target Discovery
ISBN/ISSN/Other
- ISSN: 1522-1547