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Evidence for a GABA-mediated cerebellar inhibition of the inferior olive in the cat

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Author

Summary, in English

1. Climbing fibres were activated by peripheral nerve stimulation at 'high' frequencies (greater than 3 Hz) for 15-25 s and then at 0.9 Hz for about 1 min. The high frequency activation induced a post-conditioning inhibition, lasting up to about 1 min, of climbing fibre responses recorded from the cerebellar surface. 2. Electrolytic lesions were made in the superior cerebellar peduncle (brachium conjunctivum). After the lesion, the post-conditioning inhibition was completely eliminated. 3. Injections of the GABA-receptor blocker bicuculline methiodide into the inferior olive reversibly blocked the post-conditioning inhibition. 4. The results support the hypothesis proposed by Andersson and Hesslow (1987a), that post-conditioning inhibition is mediated by a GABA-ergic interposito-olivary pathway.

Publishing year

1988

Language

English

Pages

450-456

Publication/Series

Experimental Brain Research

Volume

72

Issue

3

Document type

Journal article

Publisher

Springer

Topic

  • Neurosciences

Keywords

  • Cerebellum
  • Inferior olive
  • Interposito-olivary pathway
  • Brachium conjunctivum
  • GABA

Status

Published

Research group

  • Neurophysiology
  • Associative Learning

ISBN/ISSN/Other

  • ISSN: 0014-4819