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A von Willebrand factor-binding protein from Staphylococcus lugdunensis

På svenska

Author

  • M Nilsson
  • J Bjerketorp
  • A Wiebensjo
  • Åsa Ljungh
  • L Frykberg
  • B Guss

Summary, in English

In the present study, a phage display library covering the genome of Staphylococcus lugdunensis, was affinity-selected against von Willebrand factor (vWf). This led to the identification of a gene, vwbl, encoding a Putative cell surface protein of 2060 amino acids, denoted vWbl. The deduced protein has an overall organisation typical of staphylococcal cell Surface proteins, with an N-terminal signal peptide, and a C-terminal cell wall sorting signal. The vWf-binding part is located in repetitive domains and antibodies against vWbl or vWf can inhibit the binding. Southern blot analysis showed that vwbl was present in the 12 S. lugdunensis strains tested. (C) 2004 Federation of European Microbiological Societies.

Publishing year

2004

Language

English

Pages

155-161

Publication/Series

FEMS Microbiology Letters

Volume

234

Issue

1

Document type

Journal article

Publisher

Oxford University Press

Topic

  • Microbiology in the medical area

Keywords

  • von Willebrand factor
  • display
  • phage
  • coagulase-negative staphylococci
  • Staphylococcus lugdunensis
  • adhesin
  • LPXTG motif

Status

Published

ISBN/ISSN/Other

  • ISSN: 1574-6968