The browser you are using is not supported by this website. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Please use a modern browser to fully experience our website, such as the newest versions of Edge, Chrome, Firefox or Safari etc.

Expression of VEGF and VEGF Receptors in Childhood Precursor B-cell Acute Lymphoblastic Leukemia Evaluated by Immunohistochemistry.

På svenska

Author

  • Eva Diffner
  • Fredrika Gauffin
  • Lola Anagnostaki
  • Ann Nordgren
  • Bertil Gustafsson
  • Birgitta Sander
  • Britt Gustafsson
  • Jenny L Persson

Summary, in English

Perturbation in the expression and signaling pathways of vascular endothelial growth factor (VEGF) has been linked to pathogenesis of hematologic malignancies. We investigated the expression and clinical importance of VEGF and two of its receptors, VEGFR-1 and VEGFR-2, in childhood precursor B-cell acute lymphoblastic leukemia (pre-B ALL) by using immunohistochemistry. These angiogenic proteins were expressed in the majority of leukemic bone marrow samples. Notably, pre-B ALL patients had significantly increased expression of VEGFR-1 compared with no expression in the nonmalignant group, indicating a link between VEGFR-1 protein expression and pre-B ALL. These novel findings suggest that VEGFR-1 may have clinical importance in childhood pre-B ALL.

Publishing year

2009

Language

English

Pages

696-701

Publication/Series

Journal of Pediatric Hematology/Oncology

Volume

31

Document type

Journal article

Publisher

Lippincott Williams & Wilkins

Topic

  • Pediatrics

Status

Published

Research group

  • Pathology, Malmö
  • Experimental Cancer Research, Malmö

ISBN/ISSN/Other

  • ISSN: 1536-3678