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A meroterpenoid NF-kappa B inhibitor and drimane sesquiterpenoids from asafetida

På svenska

Author

  • Giovanni Appendino
  • Lucia Maxia
  • Marcelo Bascope
  • Peter J. Houghton
  • Gonzalo Sanchez-Duffhues
  • Eduardo Munoz
  • Olov Sterner

Summary, in English

Investigation of an acetone extract from asafetida afforded two drimane sesquiterpene dienones (fetidones A and B, 1a,b) and several known sesquiterpene coumarin ethers, one of which (8-acetoxy-5-hydroxyumbelliprenin, 2a) showed potent and specific NF-kappa B-inhibiting properties. This, coupled to a negligible cytotoxicity, qualifies 2a as a new anti-inflammatory chemotype, and its occurrence in asafetida might rationalize the use of this gum resin to alleviate and prevent colon inflammatory disturbances.

Publishing year

2006

Language

English

Pages

1101-1104

Publication/Series

Journal of Natural Products

Volume

69

Issue

7

Document type

Journal article

Publisher

The American Chemical Society (ACS)

Topic

  • Organic Chemistry

Status

Published

ISBN/ISSN/Other

  • ISSN: 0163-3864