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L-DOPA-induced dyskinesia: cellular mechanisms and approaches to treatment.

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Author

Summary, in English

L-DOPA-induced dyskinesia (LID) is a common complication of the treatment of Parkinson's disease, and its precise mechanisms have long remained unknown. Rodent models of LID provide a tool to dissect the impact of specific factors on the development and expression of dyskinetic movements. This short review will summarize recent findings from rodent studies that have consolidated and considerably expanded our mechanistic understanding of LID. Based on the experimental findings, the review will propose a chart of possible treatment options acting on different pathophysiological levels.

Publishing year

2007

Language

English

Pages

263-267

Publication/Series

Parkinsonism & Related Disorders

Volume

13 Suppl 3

Document type

Journal article

Publisher

Elsevier

Topic

  • Neurology

Status

Published

Research group

  • Basal Ganglia Pathophysiology

ISBN/ISSN/Other

  • ISSN: 1873-5126