Intratumoral IL-7 delivery by mesenchymal stromal cells potentiates IFNgamma-transduced tumor cell immunotherapy of experimental glioma.

Summary, in English

The present study reports regression of pre-established experimental rat gliomas as a result of combining peripheral immunization using interferon gamma (IFNgamma) transduced autologous tumor cells with local intratumoral delivery of interleukin 7 (IL-7) by mesenchymal stromal cells. IL-7 alone significantly decreased the tumor area and this effect was enhanced with IFNgamma immunization. A higher density of intratumoral T-cells was observed in animals receiving combined therapies compared to rats receiving either cytokine alone suggesting that the therapeutic effect is dependent on a T-cell response.

• Author: Salina Gunnarsson; Daniel Bexell; Andreas Svensson; Peter Siesjö; Anna Darabi; Johan Bengzon
• Department/s: Neurosurgery; StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
• Publishing year: 2010
• Language: English
• Pages: 140-144
• Publication/Series: Journal of Neuroimmunology
• Volume: 218
• Issue: 1-2
• Links: http://www.ncbi.nlm.nih.gov/pubmed/19914721?dopt=Abstract; http://dx.doi.org/10.1016/j.jneuroim.2009.10.017
• Document type: Journal article
• Publisher: Elsevier
• Topic: Neurology
• Status: Published
• ISBN/ISSN/Other: ISSN: 1872-8421