The dasyscyphins A similar to C and niveulone, new biologically active compounds from the ascomycete Dasyscyphus niveus

Summary, in English

In the course of a screening for cytotoxic Compounds from fungi four new terpenoid metabolites, named dasyscyphins A, B, C, and niveulone were isolated from fermentations of Dasyscyphus niveus strain A0101. While dasyscyphin A (1) exhibited no significant biological activities in our test systems dasyscyphin B (2) and dasyscyphin C (3) showed cytotoxic activities against human (HepG2, Hela S3, U937, Colo-320, Jurkat) cell lines with IC50-values of 0.5 similar to 3 mu g/ml while the activity of niveulone (4) was less pronounced. Only modest or weak antibiotic properties were observed for (2) and (3).

• Author: V Mierau; Veronica de la Parra; Olov Sterner; T Anke
• Department/s: Centre for Analysis and Synthesis
• Publishing year: 2006
• Language: English
• Pages: 53-56
• Publication/Series: Journal of Antibiotics
• Volume: 59
• Issue: 1
• Links: http://www.jstage.jst.go.jp/article/antibiotics/59/1/59_53/_article
• Document type: Journal article
• Publisher: Japan Antibiotics Research Association
• Topic: Organic Chemistry
• Keywords: activities; cytotoxic; Dasyscyphus niveus; niveulone; dasyscyphins; A similar to C
• Status: Published
• ISBN/ISSN/Other: ISSN: 0021-8820