iNOS affects matrix production in distal lung fibroblasts from patients with mild asthma.

Summary, in English

A high level of exhaled nitric oxide (NO) is a marker for inflammation in the airways of asthmatic subjects. However, little is known about how NO and inducible nitric oxides synthase (iNOS) activity may affect remodelling in the distal lung. We hypothesized that there is a link between iNOS and ongoing remodelling processes in the distal lung of mild asthmatics.

• Author: Anna-Karin Larsson Callerfelt; Maria Weitoft; Kristian Nihlberg; Leif Bjermer; Gunilla Westergren-Thorsson; Ellen Tufvesson
• Department/s: EpiHealth: Epidemiology for Health; Lung Biology; Respiratory Medicine, Allergology, and Palliative Medicine; Lung physiology and biomarkers
• Publishing year: 2015
• Language: English
• Pages: 64-71
• Publication/Series: Pulmonary Pharmacology & Therapeutics
• Volume: 34
• Issue: sep 9
• Full text: - 475 kB; Download statistics
• Links: http://www.ncbi.nlm.nih.gov/pubmed/26362859?dopt=Abstract; http://dx.doi.org/10.1016/j.pupt.2015.09.003
• Document type: Journal article review
• Publisher: Elsevier
• Topic: Respiratory Medicine and Allergy
• Status: Published
• Research group: Lung Biology; Lung physiology and biomarkers
• ISBN/ISSN/Other: ISSN: 1522-9629