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Distribution of pancreatic polypeptide and peptide YY.

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Author

Summary, in English

The cellular distribution of PP and PYY in mammals is reviewed. Expression of PP is restricted to endocrine cells mainly present in the pancreas predominantly in the duodenal portion (head) but also found in small numbers in the gastro-intestinal tract. PYY has a dual expression in both endocrine cells and neurons. PYY expressing endocrine cells occur all along the gastrointestinal tract and are frequent in the distal portion. Islet cells expressing PYY are found in many species. In rodents they predominate in the splenic portion (tail) of the pancreas. A limited expression of PYY is found also in endocrine cells in the adrenal gland, respiratory tract and pituitary. Peripheral, particularly enteric, neurons also express PYY as does a restricted set of central neurons.

Publishing year

2002

Language

English

Pages

251-261

Publication/Series

Peptides

Volume

23

Issue

2

Document type

Journal article

Publisher

Elsevier

Topic

  • Cell and Molecular Biology

Keywords

  • Endocrine Glands/metabolism
  • Human
  • Microscopy
  • Fluorescence
  • Neurons/metabolism
  • Pancreas/*metabolism
  • Pancreatic Polypeptide/*biosynthesis
  • Peptide YY/*metabolism
  • Respiratory System/metabolism
  • Rats
  • Animal
  • Spleen/metabolism
  • Support
  • Non-U.S. Gov't
  • Adrenal Glands/metabolism

Status

Published

ISBN/ISSN/Other

  • ISSN: 1873-5169