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Comparative analysis of human and bovine protein kinases reveals unique relationship and functional diversity

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Author

Summary, in English

Reversible protein phosphorylation by protein kinases and phosphatases is a common event in various cellular processes. The eukaryotic protein kinase superfamily, which is one of the largest superfamilies of eukaryotic proteins, plays several roles in cell signaling and diseases. We identified 482 eukaryotic protein kinases and 39 atypical protein kinases in the bovine genome, by searching publicly accessible genetic-sequence databases. Bovines have 512 putative protein kinases, each orthologous to a human kinase. Whereas orthologous kinase pairs are, on an average, 90.6% identical, orthologous kinase catalytic domain pairs are, on an average, 95.9% identical at the amino acid level. This bioinformatic study of bovine protein kinases provides a suitable framework for further characterization of their functional and structural properties.

Publishing year

2011

Language

English

Pages

587-591

Publication/Series

Genetics and Molecular Biology

Volume

34

Issue

4

Document type

Journal article

Publisher

Sociedade Brasileira de Genética

Topic

  • Medicinal Chemistry

Keywords

  • aPK
  • bovine
  • ePK
  • kinome

Status

Published

ISBN/ISSN/Other

  • ISSN: 1678-4685