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Fluorescence monitoring of a topically applied liposomal temoporfin formulation and photodynamic therapy of nonpigmented skin malignancies.

På svenska

Author

  • Niels Bendsoe
  • Linda Persson
  • Ann Johansson
  • Johan Axelsson
  • Jenny Svensson
  • Susanna Grafe
  • Tilmann Trebst
  • Stefan Andersson-Engels
  • Sune Svanberg
  • Katarina Svanberg

Summary, in English

Meso-tetra(hydroxyphenyl)chlorin (mTHPC) (INN: Temoporfin) is a potent photodynamically active substance in clinical use today. Usually, the substance is given systemically and a known drawback with this administration route is a prolonged skin light sensitization. For the first time to our knowledge, a liposomal Temoporfin gel formulation for topical application was studied in connection with photodynamic therapy (PDT) of nonpigmented skin malignancies in humans. Intervals of 4 hr between drug administration and light irradiation were used. Sensitizer distribution within tumor and surrounding normal skin was investigated by means of point monitoring and imaging fluorescence spectroscopy before, during, and after PDT, showing high tumor selectivity. Furthermore, the bleaching of Temoporfin was studied during the PDT procedure by monitoring the fluorescence following excitation by using a therapeutic light. A 30−35% light-induced photometabolization was shown. No pain occurred during or after treatment. It was also observed that the treated area did not show any swollen tissue or reddening, as is often seen in PDT using topical δ-aminolevulinic acid. On controlling the patients one week after treatment, healing progress was observed in several patients and no complications were registered.

Department/s

Publishing year

2007

Language

English

Pages

117-126

Publication/Series

Journal of Environmental Pathology and Toxicology

Volume

26

Issue

2

Document type

Journal article

Publisher

Begell House

Topic

  • Other Clinical Medicine
  • Clinical Medicine

Status

Published

ISBN/ISSN/Other

  • ISSN: 2162-6537