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Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors

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Author

  • Xuri Li
  • Marc Tjwa
  • Lieve Moons
  • Pierre Fons
  • Agnes Noel
  • Annelii Ny
  • Jian Min Zhou
  • Johan Lennartsson
  • Hong Li
  • Aernout Luttun
  • Annica Pontén
  • Laetitia Devy
  • Ann Bouche
  • Hideyasu Oh
  • Ann Manderveld
  • Silvia Blacher
  • Davi Communi
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Summary, in English

The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore, PDGF-CC induced the differentiation of bone marrow cells into smooth muscle cells and stimulated their growth during vessel sprouting. Moreover, delivery of PDGF-CC enhanced postischemic revascularization of the heart and limb. Modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases.

Publishing year

2005

Language

English

Pages

118-127

Publication/Series

Journal of Clinical Investigation

Volume

115

Issue

1

Document type

Journal article

Publisher

The American Society for Clinical Investigation

Topic

  • Cell and Molecular Biology

Status

Published

ISBN/ISSN/Other

  • ISSN: 0021-9738