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Novel insights in drug metabolism by MS imaging.

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Author

Summary, in English

During the last decade, lateral and temporal localization of drug compounds and their metabolites have been demonstrated and dynamically developed using MS imaging. The pharmaceutical industry has recognized the potential of the technology that provides simultaneous distribution and quantitative data. In this review, we present the latest technological achievements and summarize applications of drug imaging focusing on studies about metabolites by MALDI-MS imaging. We also introduce potential areas with pharmaceutical applications that are currently under exploration, including pharmacological, toxicological characterizations and metabolic enzyme localization in comparison with drug and metabolite distribution.

Publishing year

2016

Language

English

Pages

575-588

Publication/Series

Bioanalysis

Volume

8

Issue

6

Document type

Journal article review

Publisher

Future Science

Topic

  • Pharmacology and Toxicology

Keywords

  • Drug Metabolism and Mass Spectrometry Imaging

Status

Published

ISBN/ISSN/Other

  • ISSN: 1757-6180