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Effects of luminal stimuli on polyamine metabolism in the small intestine of the rat : the role of enteric nerves

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Author

  • M Jansson
  • B O Nilsson
  • E Rosengren
  • J. Ekström
  • O Lundgren

Summary, in English

The aim of this study was to investigate to what extent polyamine metabolism in the small intestine of the rat is controlled by the enteric nervous system. Polyamine metabolism was followed by measuring the activity of ornithine decarboxylase (ODC) and in some instances also the content of polyamines (putrescine, spermidine and spermine). ODC activity in the intestine was increased when intraluminal pressure was increased and 3 h after placing cholera toxin in the intestinal lumen. Cholera toxin also increased the tissue putrescine content. Atropine or hexamethonium given i.v. did not influence the evoked changes of ODC activity. The pressure induced changes were not decreased by placing lidocaine on the serosal surface. On the other hand, the ODC activity of control segments were decreased by hexamethonium or atropine. The presence of glucose in the intestinal perfusate did not augment tissue ODC activity, neither did the heat stable enterotoxin from Escherichia coli (STa). It is concluded that the effect on polyamine metabolism evoked by luminal pressure or cholera toxin seems not to be mediated via nerves, while nerves seem to influence ODC activity during control conditions. The experiments with enterotoxins suggest that cAMP is the intracellular second messenger controlling intestinal ODC activity.

Publishing year

1993-12

Language

English

Pages

90-483

Publication/Series

Acta Physiologica Scandinavica

Volume

149

Issue

4

Document type

Journal article

Publisher

Wiley-Blackwell

Keywords

  • Animals
  • Cholera Toxin
  • Enteric Nervous System
  • Intestine, Small
  • Ornithine Decarboxylase
  • Polyamines
  • Pressure
  • Rats
  • Rats, Sprague-Dawley
  • Time Factors

Status

Published

Research group

  • Vascular Physiology

ISBN/ISSN/Other

  • ISSN: 0001-6772