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Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging

På svenska

Author

  • D Ilver
  • A Arnqvist
  • J Ogren
  • Inga-Maria Frick
  • D Kersulyte
  • E T Incecik
  • D E Berg
  • A Covacci
  • L Engstrand
  • T Boren

Summary, in English

The bacterium Helicobacter pylori is the causative agent for peptic ulcer disease. Bacterial adherence to the human gastric epithelial lining is mediated by the fucosylated Lewis b (Leb) histo-blood group antigen. The Leb-binding adhesin, BabA, was purified by receptor activity-directed affinity tagging. The bacterial Leb-binding phenotype was associated with the presence of the cag pathogenicity island among clinical isolates of H. pylori. A vaccine strategy based on the BabA adhesin might serve as a means to target the virulent type I strains of H. pylori.

Publishing year

1998

Language

English

Pages

373-377

Publication/Series

Science

Volume

279

Issue

5349

Document type

Journal article

Publisher

American Association for the Advancement of Science (AAAS)

Topic

  • Infectious Medicine

Status

Published

ISBN/ISSN/Other

  • ISSN: 1095-9203