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Experimental nerve compression and upregulation of CPON in DRG

På svenska

Author

Summary, in English

Expression of C-terminal flanking peptide of neuropeptide Y (CPON) in DRG and cell proliferation (incorporation of BrdU) in sciatic nerve of rats following chronic nerve compression (silicone tubes with different internal diameters) was studied by immunocytochemistry. An increased number of CPON-positive neurons and cells incorporating BrdU was induced on the compressed side, most pronounced when a tight tube was used, while no cells expressed CPON or BrdU in intact nerves. The increase was transient and declined with time. Nerve compression induces transient cell proliferation in the nerve and expression of CPON in nerve cell bodies, but this is of a lesser magnitude than those following nerve transection.

Publishing year

2001

Language

English

Pages

3783-3786

Publication/Series

NeuroReport

Volume

12

Issue

17

Document type

Journal article

Publisher

Lippincott Williams & Wilkins

Topic

  • Neurosciences

Status

Published

Research group

  • Hand Surgery, Malmö

ISBN/ISSN/Other

  • ISSN: 1473-558X